Mitragyna speciosa (Kratom) is a plant indigenous to some parts of Asia. Nelsen, J. L., Lapoint, J., Hodgman, M. J., and Aldous, K. M. (2010), ‘Seizure and coma following kratom (Mitragyna speciosa) exposure', Journal of Medical Toxicology, Volume 6, pp. 424-426. Like any drug or medicine, people's reactions vary and some people could possibly have an allergic or other unusual reaction to kratom, even if they used it responsibly.

Takayama, H., Ishikawa, H., Kurihara, M. et al. (2002), ‘Studies on the synthesis and opioid agonistic activities of mitragynine-related indole alkaloids: Discovery of opioid agonists structurally different from other opioid ligands', Journal of Medicinal Chemistry, Volume 45, pp. 1949-1956.

Ketum consumption is accepted as an aid to hard work that augment incomes to support families (Assanangkornchai et al., 2006 ). Most family members expressed no reservations about male family members habitually using kratom (Assanangkornchai et al., 2006 ). Kratom users are viewed as hard‐working people, as compared to users of cannabis, alcohol, and tobacco, who are labelled as lazy and bad people, possibly because they are seen to be indulging in the habit for their individual pleasure (Saingam et al., 2012 ). Kratom users also do not engage in bullying, hurting, quarrelling, or fighting, unlike alcohol users (Saingam et al., 2012 ).

In recent years, products sold in Germany and Sweden under the name ‘Krypton' as enhanced kratom preparations turned out to contain caffeine and synthetic -desmethyltramadol (ODT) as adulterants ODT is a bioactive metabolite of the synthetic opioid analgesic tramadol and was apparently added to the Full Article herbal preparations to mimic the sedative-narcotic effects of kratom.

Parthasarathy, S., Ramanathan, S., Ismail, S. et al. (2010), ‘Determination of mitragynine in plasma with solid-phase extraction and rapid HPLC-UV analysis, and its application to a pharmacokinetic study in rat', Analytical and Bioanalytical Chemistry, Volume 397, pp. 2023-2030.
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